Drop Tables with Bigger size

We have a mysql database with a size of 2 TB, in which we have for to five big tables ranging from 110GB to 350GB. When we try to drop these tables the mysql goes to the defunct mode and hangs in that state for a long time. Is there a solution to drop these tables without mysql hanging. We have a machine which has a memory of 122GB and swap of 60 GB. We use an InnoDB Engine Hope the information suffices kindly help us with this issue