Any recommendation on my.cnf on aws.large instance?

Any best recommendation variables for my.cnf on percona server on a high 256GB RAM and 32 CPU with 4000 IOPS?

How about below ones?

> innodb_buffer_pool_size=180G 
> innodb_buffer_pool_instances=16
> innodb_flush_neighbors=0

any other recommendations on Mysql percona 5.6?